OneHealth Conserved Target Prioritizer
Identifying conserved vaccine or therapeutic targets for an emerging or re-emerging virus using genomic surveillance, immune evidence, protein structure, host interaction, and literature data.
Goal
Identify conserved vaccine or therapeutic targets for an emerging or re-emerging virus using genomic surveillance, immune evidence, protein structure, host interaction, and literature data.
Three-Day MVP
Select one virus family and one narrowly defined product objective. Retrieve human and animal sequences, measure conservation and lineage coverage, annotate epitopes and functional domains, identify host interactions and escape mutations, and rank 10–20 candidate targets.
The final output should be a transparent target dossier rather than a claim that a vaccine or antiviral has been designed.
Evaluation
Recovery of established targets, conservation across host species and lineages, evidence density, structural accessibility, and stability of rankings under alternative weighting schemes.
Team
Team assignments are being finalized ahead of the codeathon. Participants can review project teams, and request reassignment, in the shared participant spreadsheet circulated by the organizing team.