Projects.
Starting points for the NIAID-BRCs AI Codeathon 2.0, September 16-18, 2026 at Argonne National Laboratory — sketched by the organizing team, to be developed by the teams that take them on.
Each entry below is a one-slide pitch — enough to form balanced teams around, and no more. Scope, methods, and success criteria are all still open. Teams develop them into full project charters by August 28, 2026.
The 2026 slate
11 projects- 01
Evidence-Grounded Pathogen Knowledge Extraction
A reusable literature-curation service that extracts pathogen-related claims and maps them to BRC entities and schemas with passage-level provenance.
Literature RAGKnowledge ExtractionProvenance Read more → - 02
AMR-Evidence Extraction, Integration, and Interoperability
Extracting antimicrobial susceptibility and genotype–phenotype evidence from literature, harmonizing AMR and virulence databases, and combining that evidence with genome-based predictive models.
AMRLiterature MiningGenotype-Phenotype Read more → - 03
AI-Driven Metadata Curation and Harmonization
Improving the findability and reuse of pathogen datasets by completing, normalizing, and connecting sparse BioProject, BioSample, SRA, and BRC metadata.
MetadataOntologiesFAIR Data Read more → - 04
Sample Metadata That Survives Analysis in Galaxy
Preserving validated sample metadata through Galaxy analysis and exporting it as a portable, standards-based record that another scientist can independently audit and reproduce.
GalaxyISA-TabMetadata Read more → - 05
Interview-Driven Workflow Construction and Repair in Galaxy
Turning a researcher’s free-form analysis request into a validated, runnable Galaxy workflow — by reusing, adapting, or building one.
GalaxyMCPWorkflows Read more → - 06
BV-BRC Copilot: Agentic Workflow Automation
Advancing and systematically evaluating BV-BRC Copilot for generating, executing, and reproducing bioinformatics workflows from research questions and published methods.
BV-BRCCopilotWorkflows Read more → - 07
Federated NIAID–BRC Data Ecosystem Assistant
One research question, one coordinated plan spanning BV-BRC, BRC Analytics, PDN, the NIAID Data Ecosystem, NCBI resources, and other participating repositories.
MCPFederationData Discovery Read more → - 08
Sewage-to-Signal: Early Warning for Immune-Escape Mutations
An AI-assisted wastewater surveillance workflow that detects pathogens of concern, tracks their prevalence, and flags emerging immune-escape and therapeutic-resistance mutations.
WastewaterSurveillanceMutations Read more → - 09
Structure-to-Function: Hypothetical Protein and Binding-Evidence Factory
Automating functional interpretation of poorly characterized pathogen proteins by combining sequence, structure, binding databases, and literature evidence.
Protein StructureFunction PredictionBinding Evidence Read more → - 10
Hypothesis2Omics: Agentic Multi-Omics Validation
Translating a biological hypothesis into a reproducible search and analysis of public transcriptomic, proteomic, metabolomic, microbiome, or immune-system datasets.
Multi-OmicsMicrobiomeGalaxy Read more → - 11
OneHealth Conserved Target Prioritizer
Identifying conserved vaccine or therapeutic targets for an emerging or re-emerging virus using genomic surveillance, immune evidence, protein structure, host interaction, and literature data.
OneHealthVaccine TargetsConservation Read more →